ABSTRACT
There is still a lack of effective treatment for radioactive iodine-refractory DTC(RAIR DTC),anaplastic thyroid cancer(ATC)and medullary thyroid cancer(MTC).Once recurrence and metastasis occur,the patient's life is seriously threatened. With the vigorous development of molecular biology of thyroid cancer,many effective molecular targets have been found. Based on one or more targets,molecular targeted drugs underwent clinical trials for the treatment of thyroid cancer,showing good development and application prospects. Sorafenib,vandetanib,lenvatinib and cabozantinib have been approved by FDA for the treatment of advanced thyroid carcinoma. Other molecular targeting inhibitors,such as axitinib and selumetinib,have passed phaseⅡ/Ⅲ clinical trials. The emergence of the drugs provides new choices for the treatment of advanced thyroid cancer and advanced MTC. The drugs have many advantages,such as strong specificity,less side effects and good curative effect,having broad prospects in the treatment of thyroid cancer.
ABSTRACT
Hospital information platform had its present situation and problems in integration introduced, and its construction contents and mode were described. The solutions from some famous foreign companies such as Orion and InterSystems were discussed from the aspects of core architecture and technical characteristics.It's pointed out that urgent requirements and the benefit balance between different companies had to be emphasized so as to develop a platform for data sharing and exchange as well as information export.
ABSTRACT
Objective To preliminary investigate and summarize the experiences of maintaining renal function and caring the cardio preoperative patients who have renal insufficiency (renal failure stage). Methods The treatment and cared for five cardio preoperative patients who had renal insufficiency were studied, those patients had been hospitalized in Peking University People′s Hospital for cardiac surgeries from June 2013 to January 2016. Results All the five patients had received preoperative renal maintenance, none of them got severe acute renal failure, and four of them had to get regular hem dialysis treatment after discharging. One of them died because of heart failure. Conclusions Renal insufficiency is a high risk for cardiac surgeries, however, it is not a contraindication for cardiac surgeries. Preoperative evaluation, preoperative caring and the application of CRRT can reduce the complications and improve the prognosis.
ABSTRACT
No abstract available.